The latest on Methuselah, health span research, and regenerative medicine
A recent study by the Mayo Clinic including more than 2,000 people, found that exercise can have an effect on grey matter and total brain volume. Both of which are involved in cognitive decline and aging. According to Mayo Clinic experts, exercise that is good for the heart (such as brisk walking, running and cycling) could also help to slow changes in the brain.
Read MoreViewing art can stimulate thought, evoke emotion, inspire conversation, and is often a social activity. A study published this month by researchers at the University College of London has shown that ‘receptive arts’ engagement could have a protective association with longevity in older adults. Read More ⇩
Read MoreLast month (November 2019), we came across a promising report (see below) of a new drug designation created by the FDA: the “Regenerative Medicine Advanced Therapy” (RMAT). This designation was actually announced back in early 2017, but we suspect many readers may not know about it yet, so we’d like to share it here!
Read MoreRemember when turning 18 or 21 years old felt like an eternity away? How is that working out for you now? It’s true that the older we get, the faster we feel time pass us by. All of us wish we had more time to do the things we love or simply spend time with our loved ones a little longer. What if you had the chance to get time back, would you do it? See how Turn Bio is working to make this a real possibility.
Read MoreIt’s common knowledge that an animal in the zoo fares better when its enclosure resembles its natural environment. Humans however, are often resistant to the notion that we’re similar in that regard. However a recent World Health Organization funded study underlines the importance of surrounding ourselves with nature and green spaces. The aim of this study was to assess the impact of residential green spaces on all-cause mortality, and the results of these studies found a significant inverse relationship between an increase in surrounding greenness and the risk of all-cause mortality.
Read MoreGiving Tuesday was created in 2012 as a day where donors could take a different approach to filling up an online virtual cart with goods. It has since grown into an international day of charitable giving, where hundreds of millions are donated every year. One of the best ways to get involved this Giving Tuesday is in your community and to causes you deem worthy of support. This year it falls today, December 3rd. So give back, whether it be to the Methuselah Foundation or another charity of your choice. Non-Profits around the world depend on generous donors like you and your ongoing support. Your donations are greatly appreciated!
Read MoreOver the past 10 years, there has been enormous attention given to serum vitamin D level and its association with human health. We therefore found it remarkable that a new study published in the New England Journal of Medicine showed no reduction in cancer or cardiovascular mortality with a median of 5 years of supplementation with 2,000 IU of vitamin D and 1 g of fish oil in nearly 17,000 men and women over age 50. This brings us to the dog metaphor in the title of this article…
Read MoreResearchers at Washington University School of Medicine have determined that sleep deprivation in humans can lead to the spread and aggregation of the Alzheimer inducing protein, Tau. These new findings suggest that Alzheimer’s disease and sleep loss are even more intimately intertwined than previously thought. Hopefully, knowledge of this critical brain process will lead to further research on how the process works and the role it plays in neurological conditions such as Alzheimer's disease.
Read MoreMany people suffering from chronic illnesses also report that they experience ‘brain fog’ or ‘sluggishness’. A recent study done at the University of Birmingham has attributed this sluggishness, (at least in part), to inflammation. Getting a better understanding of the relationships between inflammation and brain function will help us investigate other ways to treat some of these conditions in patients with chronic illnesses.
Read MoreWe had had the pleasure of attending the conference titled “Master Investor: Investing in the Age of Longevity” that took place in London, England.
Read MoreThis article introduces Reason, an astrophysicist whose passion is longevity, and focuses on Repair Biotechnologies – a company supported by the Methuselah Foundation that is looking to regenerate the thymus and reverse atherosclerosis.
Read MoreThe carotid body is a small organ that plays a role in controlling the breathing rate. In this paper, Di Giulio describes a part of the carotid body that becomes infiltrated with lymphocytes and fibrosis during aging. Much is still unknown about this organ and the effects that it’s aging has on us. As such, we think it is important to monitor scientific literature for data that tells us something we didn’t know, or that contradicts our current understanding of degenerative aging and how we might bring it under complete medical control.
Read MoreIt can be said that cancer has been cured dozens of times over in mice. Oftentimes though, the results obtained in the lab aren’t translatable to humans with the same conditions. This uncertainty often leads to misleading results, frustration, and a waste of resources. With this in mind, the EPA has recently announced that they will stop conducting or funding studies on mammals by 2035. Read More >
Read MoreWe need blood, it delivers nutrients and removes waste. However, there is considerable evidence that during human aging, the network of the smallest blood vessels, microvasculature, atrophy with age. The research group in this paper reported that topical application vitamin C to the skin caused significant regression of senile purpura. For the sake of our mission to Renew the Rivers, we hope to see more research on the aging human microvasculature and what we can do about it.
Read MoreNicotinamide adenine dinucleotide (NAD) has become increasingly popular over the past several years. It’s a metabolite that’s very important in DNA repair and energy production. For whatever reason, it’s concentration is known to decline during human aging by as much as 90%. We hope that NAD restoration in older people can restore biological function in multiple tissues, and the results of this paper are consistent with that hope.
Read MoreFor ages, dogs have been known to bring humans joy, help comfort those with anxiety & depression, reduce stress, the list goes on. But aside from the mental and emotional benefits, what effects can these animals have on our physical well being? A recent paper reviewing 10 different studies, spanning decades, and including thousands of participants showed a strong correlation between dog ownership and a lower risk of death over the long term.
Read MoreWe have started a series of articles that will be published on medium.com. The first article provides a brief history of the Methuselah Foundation and highlights Oisín Biotechnologies – a company we provided founding capital for and continued incubation services and support. With “bio-techie” Matthew Scholz as CEO, Oisín Biotechnologies is tackling aging by selectively killing senescent cells with a targeted DNA approach.
Read MoreScience is barreling toward the cure or prevention of countless diseases. Who knows how many diseases that currently run rampant will be put to rest within the next few years. In the meantime however, those living with chronic illnesses face difficult battles every day. This article, written by a professor of psychology, goes over some practical ways that people suffering from chronic illnesses can improve their outlook in the meantime.
Read MoreAutophagy- The clearing out of old, senescent cells to make room for newer, younger cells. The research group in this paper found that markers of autophagy declined during aging in rats. Could the age-related decline in autophagy be partly to blame for the increased cellular senescence and accumulation of lipofuscin with age?
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