The latest on Methuselah, health span research, and regenerative medicine
The quest for healthier and longer lives should be inclusive and understood by all around the Earth. We are happy to see Forbes Africa publish an article focused on the impact of the longevity industry in this vast and beautiful continent.
Read MoreThe Methuselah Fund or M Fund is mission-oriented and was conceived after successful angel investments by the Methuselah Foundation. The M Fund's investment thesis is based on six strategies aimed at increasing healthy longevity and its current portfolio includes four exciting companies.
Read MoreOne area of research for improving health and reducing the comorbidities of aging is brown adipose tissue. Brown adipose tissue improves energy metabolism and has protective mechanisms against obesity.
Read MoreFor a while, we have seen that anti-aging is rapidly becoming an engineering challenge rather than a mere fantasy. To this point, our Foundation is also working on helping create a professional society focused on Geroengineering. Enter, the Society of Gero-Engineering and Technology, or SGET.
Read MoreAging is a complicated process and is highly varied among individuals. We all have that friend who "doesn't look a day over 30" well into middle-age, and the less fortunate friend who isn't aging "gracefully". You may notice aging variability within your own body. Perhaps you have overall excellent health, but your digestion has slowed or you have sleep-pattern changes. Research shows that the quantity of years is a poor estimator as an index of the aging process. Even twins often have different biological or functional ages, and within an individual, organs may age at different rates.
Read MoreOur friends at LEAF took the time to ask some interesting questions to our CEO and longevity community pioneer, David Gobel. We hope you enjoy his answers to these great questions.
Read MoreWe are excited to start seeing one of our initiatives getting more press coverage. Oisin Biotechnologies and its approach to senolytics is something we are proud of. We invite you to learn more at oisinbio.com!
Read MoreWorldwide, lifespans are predicted to increase, with South Korea leading the pack. South Korean women born in 2030 are expected to live an average of 90.8 years, an increase of 6.6 years from those born in 2010.
Read MoreFor centuries, man has been attempting to extend the healthy human lifespan by investigating the correlation between health and the microbiome. In the past, these methods have been largely unsuccessful. New research is emerging that focuses on the 29 strains of E. coli that protect against age-associated diseases, causing the host to live at least 10% longer and healthier.
Read MoreWhen traveling, moving, or vacationing from a hectic schedule, many of us imagine a blue vista with rolling waves. In the longevity community, the Blue Zones hold an additional attraction because of the allure of a longer lifespan for residents of such areas.
Read MoreHave you wondered how much your physician is paid by the drug and medical device companies? The Center for Medicare and Medicaid Services has created a powerful program called Open Payments.
Read MoreWhat happens when the industry created to keep you alive pushes products that ultimately aid in your death? We are often concerned about incentives in the healthcare industry to prescribe medicine when it is not necessary and even when a simple lifestyle change would achieve the same beneficial effects.
Read MoreOver 10 years ago, we realized that investing in longevity companies has a two-fold benefit. Such investments accelerate products into the market that we all benefit from and also pours more capital into private research, resulting in breakthroughs in the longevity space.
Read MoreOne of the reasons for wanting to extend the healthy human lifespan is friendship. Different generations often have trouble relating to one another and, as your friends begin to die, loneliness spirals into a chronic condition that affects health in a negative way.
Read MoreCellular senescence is an increasingly popular topic. Dysfunctional cells have been implicated in numerous age-related dysfunctions. While the efforts to remove these senile cells have been growing, this study shows that at least one form of cellular senescence can be addressed without drugs or other high-tech interventions.
Read MoreThe four "Yamanaka factors" have been known to induce pluripotency for some time. Forced expression of these four genes has been reported to turn an adult cell into what appears to be a pluripotent stem cell, with all that entails. However, this report illustrates that stem cell differentiation is a continuum.
Read MoreIn this well crafted series of videos, an excellent case is made for preventing age-related diseases and improving the healthy human lifespan. This excellent work was done by a collaboration of Kurzgesagt - In a Nutshell and Lifespan.io.
Read MoreHere is a fun question... Can you name one hole in your body that, if sewn shut, would help you function better?
Assuming you have an anatomically normal body, the answer is none. While saying that "bad plumbing" causes Alzheimer's Disease is an oversimplification, it is a great way to quickly explain why we angel invested in Leucadia Therapeutics in 2015. The Principal Scientist, Founder, and CEO of Leucadia Therapeutics, Doug Ethell, Ph.D., had an Occam Razor's approach to AD, which was refreshing to us and an inspiration. As it turns out, the Cribriform Plate that drains cerebrospinal fluid can get ossified or clogged as you age. In AD patients, it is always significantly clogged, thus the "bad plumbing" analogy.
At Methuselah Foundation we understand that the war against AD is one that humanity cannot afford to loose. We applaud revisiting the roadmap that will lead us to a cure. Writer John Carroll analyses this imperative in the Endpoints News article titled "After yet another PhIII Alzheimer’s failure, experts try to map a path out of the wrecking field."
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